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Global • 2026-11-02, 22:58 GMT • ~1 min read

Cholesterol transport protein ABCA1 emerges as possible Parkinson's treatment target

کولیسٹرول منتقل کرنے والا پروٹین اے بی سی اے 1 پارکنسنز کے علاج کا ممکنہ ہدف بن کر سامنے آیا

कोलेस्ट्रॉल परिवहन प्रोटीन ABCA1 पार्किंसंस के इलाज का संभावित लक्ष्य बनकर उभरा

Cholesterol transport protein ABCA1 emerges as possible Parkinson's treatment target

Key points

اہم نکات

मुख्य बातें

  • Researchers at Nanjing Medical University have identified a cholesterol transport protein, ABCA1, as a possible new target for treating Parkinson's disease, in a study published in Nature Neuroscience.
  • The team found the protein was overactive in affected brain regions, where support cells pumped excess cholesterol into neighbouring nerve cells, overwhelming their waste-clearing lysosomes and helping harmful alpha-synuclein clumps build up and kill dopamine-producing neurons.
  • In a mouse model, dialling down the ABCA1 gene reduced nerve damage and improved movement, and magnesium citrate, which blocks the protein, also protected neurons.
  • نانجنگ میڈیکل یونیورسٹی کے محققین نے کولیسٹرول منتقل کرنے والے پروٹین اے بی سی اے 1 کو پارکنسنز کی بیماری کے علاج کا ممکنہ نیا ہدف قرار دیا ہے، یہ تحقیق نیچر نیورو سائنس میں شائع ہوئی ہے۔ ٹیم نے پایا کہ متاثرہ دماغی علاقوں میں یہ پروٹین زیادہ سرگرم تھا، جہاں معاون خلیے اضافی کولیسٹرول پڑوسی اعصابی خلیوں میں دھکیل رہے تھے، جس سے ان کے فضلہ صاف کرنے والے لائسوسومز بھر گئے اور نقصان دہ الفا سینوکلین کے گچھے بن کر ڈوپامائن بنانے والے خلیے مرنے لگے۔ چوہوں کے تجربے میں اے بی سی اے 1 جین کو کم کرنے سے اعصابی نقصان کم ہوا اور حرکت بہتر ہوئی، اور میگنیشیم سائٹریٹ، جو اس پروٹین کو روکتا ہے، نے بھی خلیوں کو محفوظ رکھا۔ محققین نے خبردار کیا ہے کہ انسانوں پر تجربے ابھی باقی ہیں۔
  • नानजिंग मेडिकल यूनिवर्सिटी के शोधकर्ताओं ने कोलेस्ट्रॉल परिवहन प्रोटीन ABCA1 को पार्किंसंस रोग के इलाज का संभावित नया लक्ष्य बताया है, यह अध्ययन नेचर न्यूरोसाइंस में प्रकाशित हुआ है। टीम ने पाया कि प्रभावित मस्तिष्क क्षेत्रों में यह प्रोटीन अत्यधिक सक्रिय था, जहाँ सहायक कोशिकाएँ अतिरिक्त कोलेस्ट्रॉल पड़ोसी तंत्रिका कोशिकाओं में धकेल रही थीं, जिससे उनके अपशिष्ट साफ़ करने वाले लाइसोसोम भर गए और हानिकारक अल्फ़ा-सिन्यूक्लिन के गुच्छे बनकर डोपामाइन बनाने वाली कोशिकाएँ मरने लगीं। चूहों के प्रयोग में ABCA1 जीन को कम करने से तंत्रिका क्षति घटी और गति सुधरी, और मैग्नीशियम साइट्रेट, जो इस प्रोटीन को रोकता है, ने भी कोशिकाओं को सुरक्षित रखा। शोधकर्ताओं ने चेतावनी दी है कि मनुष्यों पर परीक्षण अभी बाक़ी हैं।

Researchers at Nanjing Medical University have identified a cholesterol transport protein, ABCA1, as a possible new target for treating Parkinson's disease, in a study published in Nature Neuroscience. The team found the protein was overactive in affected brain regions, where support cells pumped excess cholesterol into neighbouring nerve cells, overwhelming their waste-clearing lysosomes and helping harmful alpha-synuclein clumps build up and kill dopamine-producing neurons. In a mouse model, dialling down the ABCA1 gene reduced nerve damage and improved movement, and magnesium citrate, which blocks the protein, also protected neurons. Human trials are still ahead, the researchers caution.

نانجنگ میڈیکل یونیورسٹی کے محققین نے کولیسٹرول منتقل کرنے والے پروٹین اے بی سی اے 1 کو پارکنسنز کی بیماری کے علاج کا ممکنہ نیا ہدف قرار دیا ہے، یہ تحقیق نیچر نیورو سائنس میں شائع ہوئی ہے۔ ٹیم نے پایا کہ متاثرہ دماغی علاقوں میں یہ پروٹین زیادہ سرگرم تھا، جہاں معاون خلیے اضافی کولیسٹرول پڑوسی اعصابی خلیوں میں دھکیل رہے تھے، جس سے ان کے فضلہ صاف کرنے والے لائسوسومز بھر گئے اور نقصان دہ الفا سینوکلین کے گچھے بن کر ڈوپامائن بنانے والے خلیے مرنے لگے۔ چوہوں کے تجربے میں اے بی سی اے 1 جین کو کم کرنے سے اعصابی نقصان کم ہوا اور حرکت بہتر ہوئی، اور میگنیشیم سائٹریٹ، جو اس پروٹین کو روکتا ہے، نے بھی خلیوں کو محفوظ رکھا۔ محققین نے خبردار کیا ہے کہ انسانوں پر تجربے ابھی باقی ہیں۔

नानजिंग मेडिकल यूनिवर्सिटी के शोधकर्ताओं ने कोलेस्ट्रॉल परिवहन प्रोटीन ABCA1 को पार्किंसंस रोग के इलाज का संभावित नया लक्ष्य बताया है, यह अध्ययन नेचर न्यूरोसाइंस में प्रकाशित हुआ है। टीम ने पाया कि प्रभावित मस्तिष्क क्षेत्रों में यह प्रोटीन अत्यधिक सक्रिय था, जहाँ सहायक कोशिकाएँ अतिरिक्त कोलेस्ट्रॉल पड़ोसी तंत्रिका कोशिकाओं में धकेल रही थीं, जिससे उनके अपशिष्ट साफ़ करने वाले लाइसोसोम भर गए और हानिकारक अल्फ़ा-सिन्यूक्लिन के गुच्छे बनकर डोपामाइन बनाने वाली कोशिकाएँ मरने लगीं। चूहों के प्रयोग में ABCA1 जीन को कम करने से तंत्रिका क्षति घटी और गति सुधरी, और मैग्नीशियम साइट्रेट, जो इस प्रोटीन को रोकता है, ने भी कोशिकाओं को सुरक्षित रखा। शोधकर्ताओं ने चेतावनी दी है कि मनुष्यों पर परीक्षण अभी बाक़ी हैं।

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