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Global • 2026-11-01, 14:50 GMT • ~1 min read

Blood test model predicts prostate cancer treatment resistance

خون کے ٹیسٹ سے پروسٹیٹ کینسر کے علاج کی مزاحمت کی پیش گوئی ممکن

रक्त परीक्षण मॉडल से प्रोस्टेट कैंसर के इलाज के प्रति प्रतिरोध का अनुमान

Key points

اہم نکات

मुख्य बातें

  • Researchers have built a blood-based model using three mRNA markers that can predict when metastatic hormone-sensitive prostate cancer is likely to stop responding to hormone treatment.
  • In a prospective study of 147 patients in China, published in Frontiers in Oncology, the model predicted progression to castration-resistant disease within a year with strong accuracy.
  • High-risk patients progressed far faster than low-risk patients, and one gene, SLC6A8, emerged as an independent risk factor that may drive the cancer's energy use.
  • محققین نے خون کے تین ایم آر این اے نشانات پر مبنی ایک ماڈل بنایا ہے جو بتا سکتا ہے کہ پھیلا ہوا ہارمون حساس پروسٹیٹ کینسر کب ہارمون علاج کا جواب دینا بند کر سکتا ہے۔ چین میں 147 مریضوں پر کی گئی تحقیق، جو فرنٹیئرز ان آنکولوجی میں شائع ہوئی، میں اس ماڈل نے ایک سال کے اندر بیماری کے بڑھنے کی درست پیش گوئی کی۔ زیادہ خطرے والے مریضوں میں بیماری کم خطرے والوں کے مقابلے میں بہت تیزی سے بڑھی، اور ایک جین ایس ایل سی 6 اے 8 ایک آزاد خطرے کا عنصر ثابت ہوا جو کینسر کی توانائی کے استعمال کو بڑھا سکتا ہے۔ مصنفین نے خبردار کیا ہے کہ طبی استعمال سے پہلے بڑے اور کئی مراکز پر مشتمل مطالعات میں اس کی تصدیق ضروری ہے۔
  • शोधकर्ताओं ने तीन एमआरएनए मार्करों पर आधारित एक रक्त-आधारित मॉडल बनाया है जो यह अनुमान लगा सकता है कि मेटास्टेटिक हार्मोन-संवेदनशील प्रोस्टेट कैंसर कब हार्मोन उपचार का जवाब देना बंद कर सकता है। चीन में 147 मरीजों पर किए गए अध्ययन में, जो फ्रंटियर्स इन ऑन्कोलॉजी में प्रकाशित हुआ, इस मॉडल ने एक साल के भीतर कैस्ट्रेशन-प्रतिरोधी रोग की ओर बढ़ने का सटीक अनुमान लगाया। उच्च जोखिम वाले मरीजों में रोग कम जोखिम वालों की तुलना में कहीं तेजी से बढ़ा, और एक जीन SLC6A8 एक स्वतंत्र जोखिम कारक के रूप में उभरा जो कैंसर के ऊर्जा उपयोग को बढ़ा सकता है। लेखकों ने चेतावनी दी है कि नैदानिक उपयोग से पहले बड़े, बहु-केंद्र अध्ययनों में इसकी पुष्टि जरूरी है।

Researchers have built a blood-based model using three mRNA markers that can predict when metastatic hormone-sensitive prostate cancer is likely to stop responding to hormone treatment. In a prospective study of 147 patients in China, published in Frontiers in Oncology, the model predicted progression to castration-resistant disease within a year with strong accuracy. High-risk patients progressed far faster than low-risk patients, and one gene, SLC6A8, emerged as an independent risk factor that may drive the cancer's energy use. The authors caution the findings need validation in larger, multi-centre studies before clinical use.

محققین نے خون کے تین ایم آر این اے نشانات پر مبنی ایک ماڈل بنایا ہے جو بتا سکتا ہے کہ پھیلا ہوا ہارمون حساس پروسٹیٹ کینسر کب ہارمون علاج کا جواب دینا بند کر سکتا ہے۔ چین میں 147 مریضوں پر کی گئی تحقیق، جو فرنٹیئرز ان آنکولوجی میں شائع ہوئی، میں اس ماڈل نے ایک سال کے اندر بیماری کے بڑھنے کی درست پیش گوئی کی۔ زیادہ خطرے والے مریضوں میں بیماری کم خطرے والوں کے مقابلے میں بہت تیزی سے بڑھی، اور ایک جین ایس ایل سی 6 اے 8 ایک آزاد خطرے کا عنصر ثابت ہوا جو کینسر کی توانائی کے استعمال کو بڑھا سکتا ہے۔ مصنفین نے خبردار کیا ہے کہ طبی استعمال سے پہلے بڑے اور کئی مراکز پر مشتمل مطالعات میں اس کی تصدیق ضروری ہے۔

शोधकर्ताओं ने तीन एमआरएनए मार्करों पर आधारित एक रक्त-आधारित मॉडल बनाया है जो यह अनुमान लगा सकता है कि मेटास्टेटिक हार्मोन-संवेदनशील प्रोस्टेट कैंसर कब हार्मोन उपचार का जवाब देना बंद कर सकता है। चीन में 147 मरीजों पर किए गए अध्ययन में, जो फ्रंटियर्स इन ऑन्कोलॉजी में प्रकाशित हुआ, इस मॉडल ने एक साल के भीतर कैस्ट्रेशन-प्रतिरोधी रोग की ओर बढ़ने का सटीक अनुमान लगाया। उच्च जोखिम वाले मरीजों में रोग कम जोखिम वालों की तुलना में कहीं तेजी से बढ़ा, और एक जीन SLC6A8 एक स्वतंत्र जोखिम कारक के रूप में उभरा जो कैंसर के ऊर्जा उपयोग को बढ़ा सकता है। लेखकों ने चेतावनी दी है कि नैदानिक उपयोग से पहले बड़े, बहु-केंद्र अध्ययनों में इसकी पुष्टि जरूरी है।

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