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Global • 2026-11-01, 14:37 GMT • ~1 min read

ANDES trial: less bleeding with blood thinners after heart device, but clot signal emerges

اینڈیز ٹرائل: دل کے آلے کے بعد خون پتلا کرنے والی دوا سے خون کم بہا، لیکن کلاٹ کا اشارہ ملا

एंडेस ट्रायल: हृदय उपकरण के बाद खून पतला करने वाली दवा से रक्तस्राव कम, लेकिन थक्के का संकेत मिला

ANDES trial: less bleeding with blood thinners after heart device, but clot signal emerges

Key points

اہم نکات

मुख्य बातें

  • One-year results from the ANDES trial show that two months of direct oral anticoagulant therapy after left atrial appendage closure gave patients with atrial fibrillation an edge over dual antiplatelet therapy, mainly through less minor bleeding — 16.6 percent against 23.7 percent.
  • There was no difference in serious bleeding, death or stroke-causing clots.
  • But device-related thrombosis was numerically higher at one year in the blood-thinner group, 5.2 percent against 2.3 percent, a difference the researchers say should be interpreted cautiously.
  • اینڈیز ٹرائل کے ایک سالہ نتائج سے معلوم ہوا ہے کہ دل کے بائیں ایٹریل اپینڈیج بند کرنے کے بعد دو ماہ تک ڈائریکٹ اورل اینٹی کوایگولنٹ تھراپی نے ایٹریل فبریلیشن کے مریضوں کو ڈوئل اینٹی پلیٹلیٹ تھراپی پر برتری دی، بنیادی طور پر کم معمولی خون بہنے کی وجہ سے — 16.6 فیصد کے مقابلے میں 23.7 فیصد۔ سنگین خون بہنے، موت یا فالج کا باعث بننے والے کلاٹ میں کوئی فرق نہیں تھا۔ لیکن ایک سال بعد آلے سے متعلق تھرومبوسس خون پتلا کرنے والی دوا والے گروپ میں عددی طور پر زیادہ تھا، 5.2 فیصد کے مقابلے میں 2.3 فیصد، جس کے بارے میں محققین کا کہنا ہے کہ اسے احتیاط سے سمجھنا چاہیے۔ یہ نتائج سان ڈیاگو میں ٹی سی ٹی 2026 میں پیش کیے گئے۔
  • एंडेस ट्रायल के एक साल के नतीजों से पता चला है कि बाएं अलिंद उपांग को बंद करने के बाद दो महीने की डायरेक्ट ओरल एंटीकोएगुलेंट थेरेपी ने अलिंद फ़िब्रिलेशन वाले मरीजों को डुअल एंटीप्लेटलेट थेरेपी पर बढ़त दी, मुख्य रूप से कम मामूली रक्तस्राव के कारण — 16.6 प्रतिशत बनाम 23.7 प्रतिशत। गंभीर रक्तस्राव, मृत्यु या स्ट्रोक पैदा करने वाले थक्कों में कोई अंतर नहीं था। लेकिन एक साल बाद उपकरण से जुड़ा थ्रोम्बोसिस खून पतला करने वाली दवा वाले समूह में संख्यात्मक रूप से अधिक था, 5.2 प्रतिशत बनाम 2.3 प्रतिशत, जिसके बारे में शोधकर्ताओं का कहना है कि इसे सावधानी से समझना चाहिए। ये नतीजे सैन डिएगो में टीसीटी 2026 में पेश किए गए।

One-year results from the ANDES trial show that two months of direct oral anticoagulant therapy after left atrial appendage closure gave patients with atrial fibrillation an edge over dual antiplatelet therapy, mainly through less minor bleeding — 16.6 percent against 23.7 percent. There was no difference in serious bleeding, death or stroke-causing clots. But device-related thrombosis was numerically higher at one year in the blood-thinner group, 5.2 percent against 2.3 percent, a difference the researchers say should be interpreted cautiously. The findings were presented at TCT 2026 in San Diego.

اینڈیز ٹرائل کے ایک سالہ نتائج سے معلوم ہوا ہے کہ دل کے بائیں ایٹریل اپینڈیج بند کرنے کے بعد دو ماہ تک ڈائریکٹ اورل اینٹی کوایگولنٹ تھراپی نے ایٹریل فبریلیشن کے مریضوں کو ڈوئل اینٹی پلیٹلیٹ تھراپی پر برتری دی، بنیادی طور پر کم معمولی خون بہنے کی وجہ سے — 16.6 فیصد کے مقابلے میں 23.7 فیصد۔ سنگین خون بہنے، موت یا فالج کا باعث بننے والے کلاٹ میں کوئی فرق نہیں تھا۔ لیکن ایک سال بعد آلے سے متعلق تھرومبوسس خون پتلا کرنے والی دوا والے گروپ میں عددی طور پر زیادہ تھا، 5.2 فیصد کے مقابلے میں 2.3 فیصد، جس کے بارے میں محققین کا کہنا ہے کہ اسے احتیاط سے سمجھنا چاہیے۔ یہ نتائج سان ڈیاگو میں ٹی سی ٹی 2026 میں پیش کیے گئے۔

एंडेस ट्रायल के एक साल के नतीजों से पता चला है कि बाएं अलिंद उपांग को बंद करने के बाद दो महीने की डायरेक्ट ओरल एंटीकोएगुलेंट थेरेपी ने अलिंद फ़िब्रिलेशन वाले मरीजों को डुअल एंटीप्लेटलेट थेरेपी पर बढ़त दी, मुख्य रूप से कम मामूली रक्तस्राव के कारण — 16.6 प्रतिशत बनाम 23.7 प्रतिशत। गंभीर रक्तस्राव, मृत्यु या स्ट्रोक पैदा करने वाले थक्कों में कोई अंतर नहीं था। लेकिन एक साल बाद उपकरण से जुड़ा थ्रोम्बोसिस खून पतला करने वाली दवा वाले समूह में संख्यात्मक रूप से अधिक था, 5.2 प्रतिशत बनाम 2.3 प्रतिशत, जिसके बारे में शोधकर्ताओं का कहना है कि इसे सावधानी से समझना चाहिए। ये नतीजे सैन डिएगो में टीसीटी 2026 में पेश किए गए।

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